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CANCER: Venom of Australian octopus may hold key to fighting melanoma

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CANCER: Venom of Australian octopus may hold key to fighting melanoma

A native Australian octopus could hold the key to fighting one of the most serious forms of melanoma, researchers have found.

An international study has found early evidence that a compound in the venom of the octopus Kaurna, also known as the southern sand octopus, could significantly slow cancer growth.

Researchers also found the venom could help fight drug resistance in patients with BRAF-mutated melanoma, which accounts for about half of all melanoma cases.

Led by researcher Maria Ikonomopoulou, scientists tested the tumour-fighting properties of a range of synthetically reproduced venom compounds.

“We looked at venom compounds derived from various marine animals, but it was specifically the peptide from the Australian southern sand octopus that stood out for its ability to safely and effectively target BRAF-mutated melanoma cells in pre-clinical models,” she said.

It is hoped the findings will provide the foundation for a highly-targeted, less toxic treatment against cancer.

“It’s still very early days. But these findings offer hope that this octopus peptide may be developed into a cancer-targeted treatment that can safely and effectively be administered even in very high doses.”

Ikonomopoulou said many patients did not respond to existing treatments for BRAF-mutated melanoma.

“While targeted therapies and immunotherapy have improved outcomes, ongoing issues with drug toxicity and resistance hinder their overall success against cancer,” she said.

“While much more research is needed, our study shows this octopus venom compound has strong therapeutic potential.”

Researchers also want to investigate whether the compound has potential against other BRAF-mutated cancers, including those of the prostate, colon, and non-small cell lung.

The study is published in the British Journal of Pharmacology’s October issue.

Ikonomopoulou has previously found that an Australian funnel-web spider compound is highly effective at killing melanoma cells, as well as cells taken from facial tumours on Tasmania devils.

 

– dpa

 

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Libya’s Flood-ravaged Derna Struggles To Cope With Thousands Of Corpses

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Residents and rescue workers in the devastated Libyan city of Derna are struggling to cope with the thousands of corpses washing up or decaying under rubble.

This is happening after a flood that smashed down buildings and swept people to sea.

The World Health Organisation (WHO) and other aid groups urged authorities in Libya to stop burying flood victims in mass graves, saying these could bring long-term mental distress to families or cause health risks if located near water.

A UN report said more than 1,000 people had so far been buried in that manner since Libya, a nation divided by a decade of conflict and political chaos, was hit on Sunday by torrential rain that caused two dams to burst.

Thousands were killed and thousands more are missing.

“Bodies are littering the streets, washing back on shore, and are buried under collapsed buildings and debris.

“In just two hours, one of my colleagues counted over 200 bodies on the beach near Derna,” Bilal Sablouh, International Committee of the Red Cross (ICRC) forensics manager for Africa, told a briefing in Geneva.

Ibrahim al-Arabi, health minister in Libya’s Tripoli-based western government, told Reuters he was certain groundwater was polluted with water mixed up with corpses, dead animals, refuse, and chemical substances.

“We urge people not to approach the wells in Derna,” he said.

Mohammad al-Qabisi, head of Derna’s Wahda Hospital, said a field hospital was treating people with chronic illnesses needing regular attention.

He said there were fears waterborne diseases would spread, but no cholera had been recorded so far.

Swathes of Derna, the centre point of the destruction in Libya’s east, were obliterated when the dams above the city broke, and the flood that swept down a usually dry riverbed brought down whole residential blocks while families were asleep.

The International Organization for Migration mission in Libya said more than 5,000 people were presumed dead, with 3,922 deaths registered in hospitals, and over 38,640 were displaced in the flood-stricken region.

The true death toll could be far higher, officials say.

“We should be afraid of an epidemic,” 60-year-old Nouri Mohamed said, at a bakery offering loaves for free. “There are still bodies underground … Now there are corpses starting to smell.”

The U.N. health agency together with the ICRC and the International Federation of the Red Cross and Red Crescent Societies called for burials to be managed better.

“We urge authorities in communities touched by tragedy to not rush forward with mass burials or mass cremations,” Kazunobu Kojima, medical officer for biosafety and biosecurity in the WHO’s Health Emergencies Programme, said in the statement.

It called for individual graves, demarcated and documented, saying that hasty interments could lead to mental anguish for families as well as social and legal problems.

The bodies of victims of trauma from natural disasters “almost never” posed a health threat, it said, unless they were in or near freshwater supplies since corpses may leak excrement.

A doctor in Derna said this week that photos were being taken of unidentified bodies before burial, in case relatives could identify them later on.

Thursday’s UN report said more than 1,000 bodies in Derna and over 100 in Al Bayda, another coastal city hit by flooding, had been buried in mass graves.

The Norwegian Refugee Council, which has a team of 100 in Libya, said dead body management was the most pressing concern.

“I’ve heard from my team that there are mass graves where rescue workers were appealing: ‘Don’t bring us food, don’t bring us water, bring us body bags’,” the NRC’s Ahmed Bayram said. 

– Reuters

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Without France, there’d be no Mali, Burkina Faso, Niger – Macron

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Malian president condoles with Macron over killing of French soldiers by jihadists

Without France’s military operations in the Sahel, “there would probably no longer be a Mali … Burkina Faso, and I’m not sure there would still be Niger”, French President Emmanuel Macron told French publication Le Point.

Macron is referring to the former colonial power’s interventions in the mid-2000s, Operations Serval and Barkhane.

French troops were moved from Mali to Niger after its military leaders cut ties with the former colonial power.

He said the interventions were done “at the request of African states” and were “successful” as his policy is facing scrutiny in the face of losing the allyship of the last remaining ally, Niger, and increasing negative sentiment from Africans.

*Niger Uranium site

He went on to explain that while these operations reflect France’s “honour” and “responsibility”, France could no longer remain involved “when there is a coup d’état, and the priority of the new regimes is not to fight terrorism” even though this is “tragic for the states concerned”.

In the interview, Macron defended his administration’s policy in the Sahel as one of partnership rather than focusing on security.

France refuses to acknowledge coup leader General Abdurahman Tchiani’s announcement that all military deals between Niger and France are terminated, and more than a thousand French troops remain stationed at a military base there. 

– Sputnik

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Ukraine Says Special Operation Troops Landed In Crimea

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Ukraine says its troops landed in Crimea, the Black Sea peninsula that was illegally annexed by Russia in 2014 and which Kyiv says it is committed to retaking.

Ukraine’s military intelligence (HUR) carried out the landing as part of a special operation and all tasks were fulfilled, said Andrey Yusov, a spokesman for the agency, on Thursday.

Russian media reported the attack took place at Cape Tarkhankut, in the far west of Crimea, and that the Ukrainian forces had been repelled.

According to the Russian news outlets Mash and Shot, which delivers their reports on the social media platform Telegram, the Ukrainians landed in rubber boats near a campsite.

Holidaymakers there were startled by gunshots and explosions, they reported.

Shots reported, citing Russian intelligence circles, that the crews of four inflatable boats about 15 to 20 men were later killed.

Yusov denied Ukrainian losses in the course of the commando action and said it was Russian forces who were weakened, although he did not give a precise number of casualties.

The battlefield claims could not be independently verified. 

– dpa

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